Royal Air Force Typhoon FGR4s have joined forces with France's air force in a coordinated attack targeting an underground arms cache in Syria used by the IS group, as stated by the UK's MoD.
The location, identified by intelligence, was assessed as housing weapons and explosive materials, the announcement noted, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to strike a number of entry passages down to the site... preliminary assessments are that the strike was effective," officials stated.
There was no evidence of any civilian casualties in the operation on Saturday evening and all the aircraft returned to base without incident, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - alternatively referred to as the so-called Islamic State - imposed extremist governance over parts of Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates the UK's leading role, and commitment to work closely with allied nations, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the area," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed patrols over Syrian airspace to "deter any efforts to regroup" of IS subsequent to its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to every member of our armed forces participating in this strike for their professionalism and their valour," the Defence Secretary added. "They were among numerous British personnel deployed over Christmas and New Year. This mission, to take out militants who endanger our safety, demonstrates how our armed forces are ready to step up, throughout the year, ensuring Britain's security within its borders and strong abroad."
In December, the United States armed forces conducted what it called a "massive strike" against Islamic State objectives in Syria, after an attack killed two US servicemembers and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still boasts roughly 5-7 thousand militants in both countries.